The Value of VOCs Analysis in Exhaled Breath for Pulmonary Benign and Malignant Lesion Diagnosis

Chinese PLA General Hospital (301 Hospital)

Status: Unknown

Conditions: Lung Neoplasm; Lung Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02965300

S2016-110-01

Details and patient eligibility

About

The purpose of this study is to analysis the volatile organic gases(VOCs) in exhaled breath of pulmonary lesion patients and healthy controls, in order to find the difference of composition and concentration among groups.

Full description

Collect the exhaled gas in pulmonary lesion patients and healthy controls, using proton transfer reaction mass spectrometry to analysis the different composition and concentration of VOCs, to find the biomarker gases of distinguishing benign and malignant lesion of lung among different groups， and try to build a diagnostic model for lung lesion.

Enrollment: 230 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• cohort 1 :

Inclusion criteria:

Patients newly diagnosed with primary lung cancer by tissue biopsy and did not receive any treatment aiming at the tumor, including chemotherapy and radiotherapy.

Age ≥ 18 years

• cohort 2： Inclusion criteria： Patients diagnosed with pulmonary benign lesion by tissue biopsy or other examination.

Age ≥ 18 years

Exclusion criteria

patients who have more than one type of carcinoma patients diagnosed type 2 diabetes mellitus patients diagnosed chronic renal failure patients diagnosed upper digestive tract ulcer patients who reject to sign the informed consent from

• cohort 3： Healthy controls Volunteers without diagnosed lung diseases and pulmonary symptoms.

Trial design

230 participants in 3 patient groups

Primary lung cancer

Description:

patients newly diagnosed with lung cancer by tissue biopsy and did not receive any treatment aiming at the tumor, including chemotherapy and radiotherapy.

Benign lung lesion

Description:

Patients diagnosed with pulmonary benign diseases.

Healthy control

Description:

Patients without any pulmonary abnormal symptoms or diseases