The Visual Plasticity During Adversity and Prosperity in Infants With Congenital Cataracts

Sun Yat-sen University

Status: Completed

Conditions: Cataract

Treatments: Procedure: bilateral cataract removal surgery for non-dense nuclear cataract; Procedure: bilateral cataract removal surgery for dense cataract

Study type: Interventional

Funder types: Other

Identifiers

NCT03593824

CCPMOH2018-China-6

Details and patient eligibility

About

Phenotypic plasticity is the ability of individuals to change their phenotypic status when exposed to environmental variations. However, whether the plastic changes show differential susceptibility in adversity and prosperity is debated and the specific pattern of plasticity remains elusive.

Here the investigators address this question by tracking the phenotypes (functional, structural, physical, and attachment traits) in two groups of infants before and after visual deprivation: one group experienced a short duration of complete deprivation (extreme adversity) and the other group experienced a long durations of partial deprivation (watered-down adversity).

Enrollment: 40 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis with dense or non-dense nuclear congenital cataract

Exclusion criteria

• no metabolic diseases, mental retardation or central nervous diseases
• had no history of inherited diseases

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

dense cataract group

Experimental group

Treatment:

Procedure: bilateral cataract removal surgery for dense cataract

non-dense nuclear cataract group

Experimental group

Treatment:

Procedure: bilateral cataract removal surgery for non-dense nuclear cataract