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The objective of this study was to evaluate vitamin B deficiency (particularly vitamin B6 deficiency) in diabetic patients in Germany in relation to the presence or absence of proteinuria, and global vascular risk.
Full description
This observational study recruited either control subjects or patients with type 2 diabetes for over 5 years and collected information on cardiovascular risk factors. Fasting blood samples and urine were collected and biomarkers of B-vitamins were measured and were related to renal function or to global cardiovascular risk. Global cardiovascular risk was calculated from established models that include Routine clinical and laboratory markers such as plasma lipids, smoking, hypertension, and BMI.
we measured the following markers: Glucose (fasting plasma glucose); HbA1C; serum creatinine; Glomerular filtration rate (GFR), urinary Albumin, C-reactive Protein, Soluble vascular cell adhesion molecule 1 (sVCAM-1), cystatin C, vitamin B1, vitamin B12, holotranscobalamin, methylmalonic acid, homocysteine, and different vitamin B6 forms.
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Inclusion criteria
Written informed consent before any study-related activities
Ambulatory subject >18 years of age
For patients with type 2 Diabetes:
Duration of diabetes ≥ 5 years
Glycated haemoglobin (HbA1C) <10%
Body mass index (BMI) 19-40 kg/m2
For healthy controls:
No diabetes (normal fasting glucose levels measured by stick)
Exclusion criteria
174 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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