The Vitamin D Dose-Response Relationship

Bispebjerg Hospital

Status: Completed

Conditions: Vitamin D Status

Treatments: Radiation: UVB

Study type: Interventional

Funder types: Other

Identifiers

NCT01074541

271-08-0461

Details and patient eligibility

About

The purpose of the study is to determine the importance of the UV intensity and the UVB dose on the Vitamin D response after UVB.

Full description

The work is addressing vitamin D production after UVB exposure and explore the importance of UVB dose and UV intensity. Four different UVB doses and four different UV intensities are used to explore these relationships.

Many assumptions have been made concerning the vitamin D production after UVB exposure but only few studies exist.

Enrollment: 55 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-65 years
• Healthy

Exclusion criteria

• Sun bed use
• Holiday or business travel south of 45 degrees latitude during trial
• Illness
• Drug addiction
• Pregnancy
• Lactating

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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55 participants in 4 patient groups

Group 1

Active Comparator group

Description:

UV intensity 10 MIN

Treatment:

Radiation: UVB

Radiation: UVB

Radiation: UVB

Radiation: UVB

Group 2

Active Comparator group

Description:

UV intensity 5 MIN

Treatment:

Radiation: UVB

Radiation: UVB

Radiation: UVB

Radiation: UVB

Group 3

Active Comparator group

Description:

UV intensity 1 MIN

Treatment:

Radiation: UVB

Radiation: UVB

Radiation: UVB

Radiation: UVB

Group 4

Active Comparator group

Description:

UV intensity 20 MIN

Treatment:

Radiation: UVB

Radiation: UVB

Radiation: UVB

Radiation: UVB