The Water-Blueberry Study

University of Oslo

Status and phase

Completed

Phase 2

Phase 1

Conditions

Cardiovascular Disease

Treatments

Drug: Blueberry juice

Study type

Interventional

Funder types

Other

Identifiers

NCT00520871

Water-Blueberry Study

REK SØR ref nr 39-03-01166

Details and patient eligibility

About

We will study the effect of supplementation of 1 L blueberry juice to participants with at least one elevated cardiovasculat risk factor.

Full description

Participants with at leat one elevated cardiovacsular risk factor, as defined as systolic blood pressure between 140 and 165 mmHg, diastolic blood pressure between 90 and 105 mmHg, low density lipoprotein (LDL) cholesterol ≥3.4 mmol/L, total/high density lipoprotein (HDL) cholesterol ratio >4 or smoking a minimum of 3 cigarettes daily.

Subjects were randomized to two groups, where the blueberry group were supplemented with 1 L blueberry juice per day for four weeks. The control group consumed an equal amount of water.

Clinical markers, as well as biomarkers of antioxidant status, oxidative stress status and inflammation were measured in blood samples before amd after the intervention period.

Enrollment

62 patients

Sex

All

Ages

30 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

30-70 years for men and 45-70 years or at least 12 months postmenopausal for women
at least one elevated cardiovascular risk factor, defined as systolic blood pressure between 140 and 165 mmHg, diastolic blood pressure between 90 and 105 mmHg, low density lipoprotein (LDL) cholesterol ≥3.4 mmol/L, total/high density lipoprotein (HDL) cholesterol ratio >4 or smoking a minimum of 3 cigarettes daily.

Exclusion criteria

clinically recognized chronic diseases as impaired renal function, diabetes mellitus, cardiovascular disease, liver or gastrointestinal disease or cancer within the last 5 years
use of lipid-lowering drugs, diuretics or hormone replacement therapy for women
Subjects with a body-mass index ≥31
with a alcohol consumption above 3 units/day for men and 1 unit/day for women
blood donation within the last six months