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Therapeutic Antibodies Against Prion Diseases From PRNP Mutation Carriers

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Completed

Conditions

Prion Diseases

Treatments

Other: blood draw

Study type

Observational

Funder types

Other

Identifiers

NCT02837705
2015-0514

Details and patient eligibility

About

The human Prion diseases can be classified into sporadic, acquired and inherited forms. Inherited forms usually manifest in higher age so there have to be factors preventing Prion propagation in young mutation carriers. Antibodies against the flexible tail of Prions have been shown to be protective in mice. The investigators intend to screen mutation carriers and controls for the presence of Prion autoantibodies.

Enrollment

213 patients

Sex

All

Ages

1 to 99 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Relatives of patients of genetic Prion diseases
  • Obtained informed consent

Exclusion criteria

  • No informed consent

Trial design

213 participants in 2 patient groups

carriers of a mutation in the Prion gene
Description:
Carriers of a mutation in the Prion gene who are either symptomatic or pre-symptomatic and who do either know or not know their mutation status.
Treatment:
Other: blood draw
family members of carriers of a mutation in the Prion gene
Description:
Relatives of confirmed PrP mutation carriers who carry two wild type alleles.
Treatment:
Other: blood draw

Trial contacts and locations

7

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Data sourced from clinicaltrials.gov

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