Therapeutic Antibodies Against Prion Diseases From PRNP Mutation Carriers

University of Zurich (UZH)

Status: Completed

Conditions: Prion Diseases

Treatments: Other: blood draw

Study type: Observational

Funder types: Other

Identifiers

NCT02837705

2015-0514

Details and patient eligibility

About

The human Prion diseases can be classified into sporadic, acquired and inherited forms. Inherited forms usually manifest in higher age so there have to be factors preventing Prion propagation in young mutation carriers. Antibodies against the flexible tail of Prions have been shown to be protective in mice. The investigators intend to screen mutation carriers and controls for the presence of Prion autoantibodies.

Enrollment: 213 patients

Sex: All

Ages: 1 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Relatives of patients of genetic Prion diseases
• Obtained informed consent

Exclusion criteria

• No informed consent

Trial design

213 participants in 2 patient groups

carriers of a mutation in the Prion gene

Description:

Carriers of a mutation in the Prion gene who are either symptomatic or pre-symptomatic and who do either know or not know their mutation status.

Treatment:

Other: blood draw

family members of carriers of a mutation in the Prion gene

Description:

Relatives of confirmed PrP mutation carriers who carry two wild type alleles.

Treatment:

Other: blood draw