Therapeutic Drug Monitoring of Fluconazole in Critically Ill Patients

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Critically Ill Patients

Treatments: Other: Sample collection

Study type: Observational

Funder types: Other

Identifiers

NCT04252027

S62242

Details and patient eligibility

About

This prospective study will research the exposure and its variability to fluconazole after longitudinal administration in critically ill patients

Full description

An open label, monocenter pharmacokinetic study will be carried out in critically ill patients, admitted at the University Hospitals Leuven, receiving multiple dose treatment with fluconazole.

The exposure to fluconazole in the ICU cohort over multiple days of treatment will be documented. Moreover, variability and the correlating covariates that can influence the fluconazole concentration, will be determined.

Enrollment: 43 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• > 18 years
• Treatment with fluconazole
• Admitted to an ICU ward

Exclusion criteria

• < 18 years
• DNR 2 or 3