Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line

Cairo University (CU)

Status and phase: Unknown; Early Phase 1

Conditions: Carcinoma; Tongue Neoplasms

Treatments: Drug: luteolin; Drug: nano-luteolin

Study type: Interventional

Funder types: Other

Identifiers

NCT03288298

CEBD-CU-2017-09-23

Details and patient eligibility

About

In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line.

Full description

This study is conducted to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line. The primary outcome is apoptosis, while the secondary outcome is cell viability.

Enrollment: 4 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC).
• Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term).
• Application of luteolin as a chemotherapeutic drug.

Exclusion criteria

• Any cancer cell line other than OSCC, TSCC and HNSCC cell lines.
• Luteolin glycosides.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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4 participants in 2 patient groups

luteolin

Experimental group

Description:

a natural extract derived flavinoids

Treatment:

Drug: luteolin

nano-luteolin

Active Comparator group

Description:

nano-particles derived from a natural extract luteolin

Treatment:

Drug: nano-luteolin