Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis

Taichung Veterans General Hospital

Status: Enrolling

Conditions: Knee Osteoarthritis

Treatments: Drug: oral hyaluronate and injection; Drug: hyaluronate injection

Study type: Interventional

Funder types: Other

Identifiers

NCT07033312

SF22377A

Details and patient eligibility

About

The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: the therapeutic effect in the combined treatment of oral nutritional supplement based on hyaluronic acid with hyaluronic acid intra-articular Injection on symptomatic knee osteoarthritis. Researchers will compare it to those who receive only hyaluronic acid injection to see if the combined treatment is better.

Participants will receive a total of three months of oral hyaluronate or placebo agents.

Enrollment: 40 estimated patients

Sex: All

Ages: 60 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Radiological evidence of osteoarthritis Ahlbäck stage I-III.
2. Had knee effusion at the suprapatellar recess under ultrasonographic examination.
3. Age between 60 and 75 years old.

Exclusion criteria

1. Rheumatological disorders
2. Accidental trauma or fractures involving knees in the past three months
3. Neuropathic pain involving lower limbs
4. Central nervous system disorders including stroke, Parkinsonism, and spinal cord disorders.
5. Depression and cognitive problems
6. Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

oral hyaluronate plus hyaluronate knee injection

Experimental group

Description:

oral hyaluronate plus hyaluronate knee injection

Treatment:

Drug: oral hyaluronate and injection

hyaluronate knee injection

Placebo Comparator group

Description:

hyaluronate knee injection

Treatment:

Drug: hyaluronate injection