Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus

Mashhad University of Medical Sciences

Status and phase: Unknown; Phase 1

Conditions: Atrophic Oral Lichen Planus; Erosive Oral Lichen Planus

Treatments: Drug: Quercetin; Drug: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01375101

88705

Details and patient eligibility

About

Lichen planus (LP) is a common chronic inflammatory mucocutaneous disease with an immunologic etiology ,which has number of different clinical forms. Alternative natural or herbal origine drugs with antioxidant and anti-inflammatory properties have been used individually or in combination with systemic corticosteroids in order to decrease adverse drug reactions.

This study was conducted to evaluate the effect of quercetin on treatment of erosive -atrophic lesions of oral lichen planus (OLP).

Enrollment: 30 estimated patients

Sex: All

Ages: 12 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• confirmation of clinical diagnosis of Atrophic and erosive lichen planus by histological examination
• two weeks wash out periods after the last treatment
• having the experience of atrophic and erosive lesion greater than 1 cm having the experience of pain and burning greater than 3.5 in VAS Score

Exclusion criteria

• confirmation of dysplasia and malignancy in histologic examination
• confirmation of lichenoid reaction in histologic examination
• pregnancy and breast feeding
• using fluorokinolon and cyclosporin which interact with quercetin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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30 participants in 2 patient groups, including a placebo group

quercetin

Active Comparator group

Description:

quercetin is one of flavonoids , and having therapeutical anti-inflammatory and antioxidant action

Treatment:

Drug: Quercetin

placebo

Placebo Comparator group

Description:

placebo capsul is produced with lactose for using in placebo/ control group.

Treatment:

Drug: placebo