Therapeutic Effects of Topical Herbal Medicine -Rhubarb Ointment on Rosacea

Chang Gung Medical Foundation

Status and phase: Completed; Phase 2

Conditions: Chinese Herbal Medicine; Rosacea

Treatments: Drug: dian dao san

Study type: Interventional

Funder types: Other

Identifiers

NCT05045469

202101000A3

Details and patient eligibility

About

The aim of this study is to investigate the effects of topical herbal medicine in the patients with rosacea.

Full description

Rosacea is a chronic inflammatory disorder which affects the cheek, nose, chin, forehead and eyes. It is typically characterized by cutaneous signs such as flushing, erythema, telangiectasia, papules, and pustules in the face. The pathogenic mechanism of rosacea is unknown, and there is no cure for rosacea. The therapeutic approaches include oral medicine, topical medicine and surgical interventions depending on the different subtypes of rosacea. The recent study demonstrates that combination therapy may be more effectively improved the symptoms of rosacea. Dian dao san is a topical herbal compound for reducing the features as flushing, erythema, papules, and pustules for years. The investigators hypothesize that dian dao san can be more beneficial in treating the patients with rosacea and improving the quality of life.

Enrollment: 24 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Willing to sign inform consent
• Aged above 20 years old with rosacea
• No treatment for rosacea within 2 weeks

Exclusion criteria

• With malignant lesion in the rosacea lesion
• Rosacea lesion with high risk of infection
• Allergy to Chinese herbal medicine patch or ointment
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups, including a placebo group

group A (dian dao san group)

Active Comparator group

Description:

Herbal medicine (dian dao san) will be applied to the lesions of rosacea twice a day. Subject will receive persistent treatment for 6 weeks.

Treatment:

Drug: dian dao san

group B( topical medicine without therapeutic effects)

Placebo Comparator group

Description:

Placebo (topical medicine without therapeutic effects) will be applied to the lesions of rosacea twice a day. Subject will receive persistent treatment for 6 weeks.

Treatment:

Drug: dian dao san