Therapeutic Fasting and Immune Aging (JÛVENILE)

Centre Hospitalier Universitaire de Saint Etienne

Status

Not yet enrolling

Conditions

Fasting

Diet, Healthy

Treatments

Dietary Supplement: Fasting mimicking diet (FMD)

Study type

Interventional

Funder types

Other

Identifiers

NCT05857241

2023-A00390-45 (Other Identifier)

21CH028

Details and patient eligibility

About

Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity/adaptability of the lymphocyte repertoire. The consequences of immunosenescence are multiple, including increased susceptibility to infections and poorer vaccine responses.

Full description

In order to fight against immunosenescence, many therapeutics are envisaged, with the aim of restoring, renewing and/or reprogramming the immune system. Among these leads, therapeutic fasting, and in particular the "fasting mimicking diet" (FMD), seems to modify the reprogramming and renewal of the immune system with, on the one hand, the elimination of inefficient "overactivated" cells and, on the other hand, the activation of hematopoietic stem cells. FMD consists of a significant reduction in food intake, limited to 3-5 days/month. The FMD seems to be the best compromise between efficacy and tolerance (already evaluated in humans, including oncology).

Enrollment

20 estimated patients

Sex

All

Ages

65+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria :

Patient affiliated or entitled to a social security scheme
Residing in a Long-Term Care Unit (LTCU) or a Facility for the Elderly Dependent (EHPAD)
A person deemed a priori, by the geriatrician member of the monitoring committee, to be capable of following the dietary recommendations required for the study.
A person deemed a priori, by the clinician in charge, to be able to follow the dietary recommendations required by the study.
Patient who has received informed information about the study and has co-signed a consent to participate in the study with the investigator.

Exclusion Criteria :

Inability and/or unwillingness to follow dietary recommendations and/or perform follow-up examinations required for the study
Iso-resource group 1 or 2 according to the AGGIR grid
BMI < 18.5 kg/m2 or recent weight loss > 5% in 1 month or recent weight loss > 10% in 6 months from previous weight
Albuminemia < 30g/l
All swallowing disorders requiring a specific diet.
Influenza vaccination received prior to inclusion
Episode of influenza or suspected influenza during the 2020-2021 season and prior to inclusion
Any acute medical or surgical event less than 2 weeks prior to inclusion
Presence of systemic inflammatory or autoimmune disease
Presence of an innate or acquired immune deficiency (including taking immunosuppressive treatment)
Presence of a chronic disease which, according to the physician, makes the follow-up of a "fasting diet" and/or the consumption of large amounts of liquids (cf. fasting diet modalities) risky (e.g. insulin-dependent or insulin-requiring diabetes, severe heart failure, severe kidney failure, active cancer, significant undernutrition...) or impossible (e.g. advanced neurodegenerative pathology).