Therapeutic Innovation in Type 2 DIABetes (IT-DIAB)

Nantes University Hospital (NUH)

Status

Unknown

Conditions

Pre-diabetes

Treatments

Other: Pre-diabetes screening

Study type

Interventional

Funder types

Other

Identifiers

NCT01218061

PROG/09/11

Details and patient eligibility

About

The main objective of the study is to follow prospectively a cohort of patients with pre-diabetes to understand the pathophysiological mechanisms involved in switching from pre-diabetes to type 2 diabetes and to identify new biomarkers of type 2 diabetes risk in this population.

Enrollment

366 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult patients (≥18 years)
Subjects with diabetes risk score ≥ 15
Subjects with impaired fasting glucose: blood glucose ≥ 1.10 g/l and < 1 .26 g/L
Subjects affiliated with an appropriate social security system

Exclusion criteria

Fasting glycemia ≥ 1.26 g/l
Fasting glycemia ≤ 1.10 g/l
Subjects previously treated with oral anti-diabetic: metformin, glitazones, inhibitors of α-glucosidase, sulfonylurea, repaglinide, inhibitors of DPP-IV, GLP-1 R agonists.
Subjects previously treated with insulin, except gestational diabetes
Severe coagulation disorders
Thrombocytopenia < 100 000/mm 3
Severe psychiatric disorders
Severe renal insufficiency (creatinine clearance < 30 ml/min)
Severe hepatic insufficiency (TP < 50%)
Alcohol abuse (> 30g/j)
Patient's opposition
Subject unable to follow the study during the 5 years of follow-up
Subject exclusion period in a previous study