Therapeutic Plasma Exchange in Thyrotoxicosis

Baskent University

Status: Completed

Conditions: Thyrotoxicosis

Treatments: Device: Therapeutic plasma exchange

Study type: Observational

Funder types: Other

Identifiers

NCT04485975

KA20/244

Details and patient eligibility

About

Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

Full description

Background: Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

Methods: The files of 27 patients who underwent preoperative TPE for thyrotoxicosis between January 1999 and February 2019 were retrospectively analyzed. The demographic and clinical features of the patients were included.

Enrollment: 27 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• thyrotoxicosis unresponsive to medication
• adverse reaction to the medications
• need for rapid treatment in patients that need urgent surgery

Exclusion criteria

• The patients who did not undergo surgery post-therapeutic plasma exchange
• Preoperative hypocalcemia,
• hemodynamically unstable patients
• patients not suitable for central catheter placement