Therapeutic Termination of Pregnancy and Psychiatric Implications (TTOP_PSY)

University of Milano Bicocca

Status: Completed

Conditions: Therapeutic Abortion With Complications; Depression, Reactive; Post Traumatic Stress Disorder; Trauma, Psychological; Personality Disorders; Reproductive Behavior

Treatments: Procedure: Clinical psychiatric examination; Diagnostic Test: Multiple psychometric questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT04080141

981/b

Details and patient eligibility

About

25 parental couples, with a prenatal diagnosis of fetal abnormality, had psychiatric evaluation for eligibility before TToP and after one year from the procedure. Women and unborn's fathers were also subjected to different psychometric questionnaires (HAM-D, HAM-A, BDI-II, PCL-5, IPDS, CTQ, CD-RISC-10).

Full description

The therapeutic interruption of pregnancy (TTOP) may have psychiatric outcomes like depression, anxiety and post-traumatic stress disorder (PTSD). Personality issues, childhood traumas and paternal consequences are too little investigated in current Literature.

The investigator's aim is exploring the contribution of maternal personality disorders and maternal history of childhood traumas to psychiatric outcomes after a TToP, paternal psychiatric outcomes and their role on their partner's psychopathological and psychiatric outcomes.

25 couples, with a prenatal diagnosis of fetal abnormality, had psychiatric evaluation for eligibility before TToP and after one year from the procedure. Women and unborn's fathers were also subjected to different psychometric questionnaires (HAM-D, HAM-A, BDI-II, PCL-5, IPDS, CTQ, CD-RISC-10).

At the time of first contact (T0) only women were subjected to a psychiatric clinical examination in order to evaluate their legal eligibility to TToP, according to Italian Law n. 194/78. At T0 women were also subjected to Hamilton's rating scale for depression (HRSD or HAM-D), Hamilton's rating scale for anxiety (HRSA or HAM-A), Beck Depression Inventory (BDI-II). At the follow up after 1 year from the first examination (T1) the parental couples were subjected to a questionnaire with multiple psychometric tests for mother and her partner. The female version included Post-traumatic stress disorder checklist (PCL-5), Iowa Personality Disorder Screen (IPDS), Beck Depression Inventory (BDI-II), Connor-Davidson Resilience Scale 10 (CD-RISC 10) and Short-Form Questionnaire on childhood trauma (CTQ-SF). The male version included Post-traumatic stress disorder checklist (PCL-5), Iowa Personality Disorder Screen (IPDS), Connor-Davidson Resilience Scale 10 (CD-RISC 10) and Short-Form Questionnaire on childhood trauma (CTQ-SF).

Enrollment: 90 patients

Sex: All

Ages: 10 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnancy
• Prenatal diagnosis of fetal abnormality
• Adequate comprehension
• Legal eligibility to TToP procedure after psychiatric clinical evaluation
• Acceptance on a voluntary basis

Exclusion criteria

• Incapacity
• Acute psychosis

Trial design

90 participants in 2 patient groups

PD+

Description:

Subjects with personality disorder

Treatment:

Diagnostic Test: Multiple psychometric questionnaire

Procedure: Clinical psychiatric examination

PD-

Description:

Subjects without personality disorder

Treatment:

Diagnostic Test: Multiple psychometric questionnaire

Procedure: Clinical psychiatric examination