Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation (APnanotecnolog)

University of Bari Aldo Moro

Status: Begins enrollment this month

Conditions: Tooth Avulsion; Tooth Crown Fracture

Treatments: Procedure: Socket Preservation

Study type: Interventional

Funder types: Other

Identifiers

NCT07371130

AlveolarPreservation

Details and patient eligibility

About

After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane.

This procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.

Full description

After tooth extraction, a progressive remodeling process occurs that is often associated with significant alveolar bone resorption, particularly in sites with compromised bony walls. Alveolar ridge preservation is a surgical procedure aimed at minimizing this physiological resorption by placing grafting materials within the extraction socket and protecting them with a barrier membrane.

In the present protocol, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.

In one study group, in addition to the surgical procedure, postoperative biostimulation using low-intensity photonic nanotechnology is applied. This adjunctive therapy is intended to enhance cellular metabolism, modulate inflammation, and accelerate both soft and hard tissue healing. The combined approach aims to preserve alveolar volume more effectively, improve the quality of regenerated tissues, and create a more favorable prosthetic environment for subsequent implant rehabilitation.

Enrollment: 20 estimated patients

Sex: All

Ages: 21 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults in good general health
• Indication for tooth extraction in sites planned for delayed implant placement
• Inability to place immediate post-extraction implants due to insufficient residual bone to ensure primary stability
• Extraction sockets presenting absence of the buccal (vestibular) bone wall
• Signed informed consent

Exclusion criteria

• Systemic conditions affecting bone healing
• Uncontrolled periodontal disease
• Smoking >10 cigarettes/day
• Pregnancy or lactation
• Use of medications interfering with bone metabolism

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Traditional Alveolar Preservation

Active Comparator group

Description:

The socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and dermal membrane

Treatment:

Procedure: Socket Preservation

therapeutic wavelengths Alveolar Preservation

Experimental group

Description:

Therapeutic wavelengths are applied as part of the alveolar preservation protocol. The extraction socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and subsequently covered with a dermal membrane to support healing and tissue regeneration.

Treatment:

Procedure: Socket Preservation