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Therapy for Reading Problems in Adults After Brain Injury

United States Department of Health and Human Services (HHS) logo

United States Department of Health and Human Services (HHS)

Status

Completed

Conditions

Cerebrovascular Accident
Brain Injuries
Dyslexia, Acquired

Treatments

Behavioral: Cognitive Therapy to Improve Reading

Study type

Interventional

Funder types

NIH

Identifiers

NCT00064805
R01HD036019

Details and patient eligibility

About

Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.

Full description

Acquired disorders of reading (acquired dyslexia) are common in patients with aphasia subsequent to left hemisphere stroke. Even when language functions recover sufficiently to enable the patient to return to work, continuing dyslexia often interferes significantly with job performance. This study will evaluate cognitive therapies for the treatment of acquired dyslexia.

Each therapy is based upon a cognitive neuropsychological model of reading; the therapies target specific types of reading deficit and stem from the question of re-learning versus re-organization of function. The therapies focus on dyslexic disorders stemming from the following underlying deficits: 1) impaired access to the orthographic word form from the visual modality (pure alexia); 2) impaired orthographic/phonologic connections (phonologic/deep dyslexia); and 3) decreased ability to hold phonologic codes in memory (phonologic text alexia).

Participants in this study will undergo a comprehensive and detailed battery of reading and reading-related tests to determine the underlying impairment causing the reading deficit. Based upon the results of these tests, the patient's dyslexic disorder will be characterized and, if appropriate, the patient will be assigned to one of the treatment programs devised specifically for that type of deficit. Treatment programs are evaluated for efficacy by comparing the accuracy and speed of reading pre- and post-treatment.

Enrollment

58 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

  • Reading deficit subsequent to stroke, traumatic brain injury, brain surgery, or other brain damage
  • Ability to attend 2-3 sessions per week for several months at Georgetown University in Washington, DC

Exclusion Criteria

  • History of developmental dyslexia or learning disabilities
  • Best corrected vision less than 20/40
  • Less than 10 years of formal education
  • Significant memory or comprehension problems

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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