There is a Value of Luteinizing Hormone Predictive of in Vitro Fertilization Treatment Outcome in Antagonist Protocols?

U.O.S. Procreazione Medicalmente Assistita e Congelamento Gameti

Status and phase: Completed; Phase 4

Conditions: Female Infertility

Treatments: Other: LH value

Study type: Interventional

Funder types: Other

Identifiers

NCT02328924

Uospmacg

Details and patient eligibility

About

This study, prospective randomized controlled trial, tried to identify a cut off value of luteinizing hormone predictive of in vitro fertilization outcome in a fixed or flexible gonadotropin-releasing hormone antagonist protocols.

202 norma-ovulatory women < 39 years were randomized to fixed or flexible group in GnRH antagonist protocols The follicular phase profile of luteinizing hormone, estradiol and progesterone in the two study groups was measured. Total number of retrieved oocytes, implantation and pregnancy rate were recorded.

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Enrollment: 213 patients

Sex: Female

Ages: 35 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1. age <39 years; (2) normal menstrual cycle (range of 26-32 days); (3) baseline follicle stimulating hormone levels < 12 IU/ml; (4) body mass index (BMI) between 18-30 Kg/m2; (5) no oral contraceptive pills taken in the last year

Exclusion criteria

• polycystic ovaries, age >39 years

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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213 participants in 2 patient groups

LH value in fixed group

Other group

Description:

LH value predictive of IVF in 104 patients entered in fixed protocol

Treatment:

Other: LH value

LH value in flexible group

Other group

Description:

LH value predictive of IVF in 109 patients entered in flexible protocols

Treatment:

Other: LH value