Thermic & Lipemic Properties of Dietary Carbohydrates (FL33)

USDA, Western Human Nutrition Research Center

Status: Completed

Conditions: Dietary Modification; Exogenous Obesity

Treatments: Other: Low Glycemic Index meals; Other: High Glycemic Index meals

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT01354574

200210295

FL33 (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to determine if consumption of meals containing carbohydrates with different glycemic index (a high glycemic index meal and a low glycemic index meal)have different effects on energy expenditure, type of metabolic fuels used for energy, blood lipids and lipoproteins, and sensations of hunger, fullness, and the hormones related to satiety.

Full description

Little is known about the metabolic effects of chronic dieting and weight cycling in humans, but limited evidence suggests that fatty acid oxidation may be depressed leading to periodic elevation of circulating lipids associated with meal ingestion and preferential storage of fat in adipose tissue. With the traditional approach of restrictive dieting failing to result in permanent weight loss and, possibly producing abnormalities in lipid metabolism, it is important to evaluate alternative approaches to achieve a healthy body weight through improved metabolism. In this study the investigators will test the postprandial metabolic effects of standard mixed meals containing carbohydrates with high glycemic index and compare these effects to responses obtained with standard mixed meals, matched for protein and fat content but containing carbohydrates with low glycemic index.

Enrollment: 28 patients

Sex: Female

Ages: 18 to 48 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index between 25 and 30 kg/m2
• Having regular menses
• Willing to refrain from restrictive dieting during the course of the study

Exclusion criteria

• Pregnant or currently planning a pregnancy
• Cigarette smoking
• Taking medications to induce weight loss or change appetite
• History of cardiovascular disease
• History of metabolic disorders, including diabetes

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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28 participants in 2 patient groups

High Glycemic Index meals

Experimental group

Description:

Three days of run-in diet with meals containing high glycemic index carbohydrates followed by test day with breakfast meal containing high glycemic index carbohydrates.

Treatment:

Other: High Glycemic Index meals

Low Glycemic Index meals

Experimental group

Description:

Three days of run-in diet with meals containing low glycemic index carbohydrates followed by test day with breakfast meal containing low glycemic index carbohydrates.

Treatment:

Other: Low Glycemic Index meals