Thermogenic Properties of Zantrex-3 (ZANTREX)

University of Copenhagen

Status: Completed

Conditions: Obesity

Treatments: Dietary Supplement: Thermogenic properties of Zantrex-3®

Study type: Interventional

Funder types: Other

Identifiers

NCT01622101

B238

Details and patient eligibility

About

Background: Zantrex-3® is a popular dietary supplement for weight control, which consists of a combination of yerba mate, guarana, caffeine and damiana. The combination has previously been shown to decrease gastric emptying and its weight controlling effects may be related to increased satiety and thermogenesis.

Objective: To investigate the effect of Zantrex-3® on energy expenditure, hemodynamic factors and subjective appetite sensations.

Design: Twenty-three men (BMI: 23.9±3.2 kg/m2, mean±SD) participated in a randomized, double-blind, placebo-controlled crossover study. The Zantrex-3® compound contained 365 mg xantines (caffeine and caffeine-like stimulants), yerba mate, guarana and damiana. The thermogenic effect was measured for 3 hours post-intake. Blood pressure (BP), heart rate (HR) and appetite ratings were assessed every half hour.

Enrollment: 23 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy,
• BMI: 23-30 kg/m2,
• Weight stable (within +/- 3 kg) two months prior to study inclusion,
• Non-smoking,
• Nonathletic (< 10 h hard physical activity), *The subjects followed a normal Danish habitual diet with rare use of hot spices

Exclusion criteria

• Change in smoking status,

• Daily or frequent use of medication,

• Suffering from metabolic diseases,

• Suffering from psychiatric diseases,

• Suffering from any other clinical condition, which would make the subject unfit to participate in the study,

  • use of dietary supplements or frequent use of medication
  • blood pressure above 160/90 mmHg

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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23 participants in 2 patient groups, including a placebo group

zantrex

Experimental group

Description:

The test compound was administered as tablets. The Zantrex-3® compound contained yerba maté, caffeine, guarana, damiana, green tea, kola nut, schizonepeta, piper nigrum, ginseng, maca root, and cocoa nut. The content of xantines (caffeine and caffeine-like stimulants) accounted for 365 mg per serving (2 capsules).

Treatment:

Dietary Supplement: Thermogenic properties of Zantrex-3®

Control

Placebo Comparator group

Description:

The placebo supplement contained rice flower and could not be distinguished from the Zantrex-3® compound with regard to colour, taste, smell or appearance.

Treatment:

Dietary Supplement: Thermogenic properties of Zantrex-3®