Thiol Disulfide Balance in Cervix Cancer

Muğla Sıtkı Koçman University

Status: Completed

Conditions: Oxidative Stress; Cervix Cancer

Treatments: Diagnostic Test: Disulphide(μmol/L); Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L); Diagnostic Test: Ischemia Modified Albumin(IU/mL)

Study type: Observational

Funder types: Other

Identifiers

NCT04258553

19/09/2018-15-4

Details and patient eligibility

About

The aim of this research is to evaluate thiol-disulfide balance in cervix cancer patients

Full description

To date various oxidative stress parameters were studied in patients with cervix cancer, however dynamic thiol disulfide hemostasis has not been previously investigated.

The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel & Neselioglu (1).

References

1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.

Enrollment: 123 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Histopathologically confirmed diagnosis of cervix cancer

Exclusion criteria

• pulmonary disease
• pulmonary hypertension
• cardiac dysfunction
• renal dysfunction
• liver disease
• chronic ischemia
• systemic inflammation
• concomitant malignancy
• patients who use vitamin A,C or E (antioxidant vitamins)
• patients who use smoke
• patients who use drink alcohol
• patients who use addictive for any drug

Trial design

123 participants in 2 patient groups

Cervix cancer

Description:

Cervix cancer n=62

Treatment:

Diagnostic Test: Ischemia Modified Albumin(IU/mL)

Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)

Diagnostic Test: Disulphide(μmol/L)

Healthy controls

Description:

Healthy volunteers n=61

Treatment:

Diagnostic Test: Ischemia Modified Albumin(IU/mL)

Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)

Diagnostic Test: Disulphide(μmol/L)