Thiol/Disulphide Homeostasis and Vascular Endothelial Growth Factor Levels in Diabetic Children

Aydin Adnan Menderes University

Status: Completed

Conditions: Periodontal Diseases

Treatments: Diagnostic Test: ELISA

Study type: Observational

Funder types: Other

Identifiers

NCT04470635

2020/114

Details and patient eligibility

About

The aim of this study to evaluate the vascular endothelial growth factor level and thiol/disulphide homeostasis in saliva of diabetic children with gingivitis.

Full description

Eighty children (44 with type 1 diabetes mellitus and 44 systemically healthy) will be recruited for the study. The children will be divided into four subgroups based on their periodontal and systemic condition: 1) systemically and periodontally healthy children, 2) systemically healthy children with gingivitis, 3) periodontally healthy children with T1DM, and 4) children with T1DM and gingivitis. The plaque index, gingival index, probing pocket depth, will recorded. The vascular endothelial growth factor level determined by ELISA. Native thiol, total thiol and disulphide levels will be measured in saliva.

Enrollment: 80 patients

Sex: All

Ages: 7 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children diagnosed as type 1 diabetes mellitus
• Age between 7-14 years

Exclusion criteria

• Having another systemic problem except type 1 diabetes mellitus
• Children carrying orthodontic appliances

Trial design

80 participants in 4 patient groups

Type 1 diabetes with gingivitis

Description:

Children with type 1 diabetes mellitus and gingivitis

Treatment:

Diagnostic Test: ELISA

Type 1 diabetes with healthy gingiva

Description:

Children with type 1 diabetes mellitus and healthy gingiva

Treatment:

Diagnostic Test: ELISA

Healthy children with gingivitis

Description:

Systemically healthy children with gingivitis

Treatment:

Diagnostic Test: ELISA

Healthy children and healthy gingiva

Description:

Systemically healthy children with healthy gingiva

Treatment:

Diagnostic Test: ELISA