Third Molar Clinical Trials: Pericoronitis Studies

University of North Carolina (UNC)

Status: Completed

Conditions: Pericoronitis

Study type: Observational

Funder types: Other

Identifiers

NCT01882270

05-2846

Details and patient eligibility

About

The purpose of this research study is to find out if the infection around 3rd molars and the resulting inflammation around the gum also produces a general systemic inflammation.

Full description

Relate signs and symptoms of mild pericoronitis, an oral clinical condition characterized by intense inflammation and pain around a lower 3rd molar, to indicators of oral and systemic inflammation in patients seeking treatment for the condition.

Enrollment: 115 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Mild signs/symptoms of pericoronitis affecting at least one lower 3rd molar with adjacent 2nd molar (spontaneous pain with localized swelling, purulence/drainage) with recommended treatment being removal of 3rd molars,
• Age 18 - 35 years,
• ASA I, II health status,
• AAP 1-3 periodontal status,
• Willingness to participate in the study,
• Geographic proximity to UNC.

Exclusion criteria

• Major signs/symptoms of pericoronitis (Temperature >101 , dysphagia, limited mouth opening <20mm incisor, facial swelling/cellulitis, severe uncontrolled discomfort),
• ASA III, IV health status,
• Medical contraindication to full mouth periodontal probing,
• AAP 4 periodontal status,
• Antibiotic treatment within the past 2 months,
• Current tobacco use,
• BMI > 29,
• Pregnancy,
• Non English speaking.

Trial design

115 participants in 1 patient group

Mild Pericoronitis

Description:

Those with mild signs/symptoms of pericoronitis affecting at least one lower 3rd molar with adjacent 2nd molar will be monitored for 12 months following study entry or 3 months for those electing to have 3rd molar extraction.