The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles.

Institute of Dermatology, Thailand

Status

Active, not recruiting

Conditions

Aging

Treatments

Drug: Epidermal Growth Factor

Study type

Interventional

Funder types

Other

Identifiers

NCT05724589

008/2565

Details and patient eligibility

About

EGF is a polypeptide that promotes cell differentiation and collagen production while decreasing melanin production. This study is designed to study its effectiveness in improving the texture and appearance of facial skin after daily topical application. We hypothesized that EGF would improve facial skin hydration, elasticity, pigmentation, and wrinkles.

Full description

All patients gave written informed consent for epidermal growth factor serum application on the face. The pilot study enrolls thirty patients compared to pre and post-serum used to evaluate facial skin hydration, transepidermal water loss, elasticity, pigmentation, and wrinkles measured by corneometer, tewameter, cutometer, visioscan, and mexameter respectively on day 0, then 8, 12, and 16 weeks. The study evaluates subject satisfaction and side effects after serum application as secondary outcomes.

Enrollment

30 estimated patients

Sex

All

Ages

40 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Thai
Mild to moderate facial skin condition, as measured by 1-2 points on the hyperpigmentation status scale or 2-3 points on the wrinkle severity grading scale.

Exclusion criteria

Use of lotions or skin care products containing ingredients such as vitamin A/C, hydroquinone, or anti-aging agents.
Sunbathing
Hypersensitivity to serum components
Pregnancy and breast-feeding
Active skin diseases such as eczema or atopic dermatitis at the application site