This Study Utilized Fermented Lingonberry Juice in a Spray Form, Allowing it to be Applied to the Mouth Four Times a Day. (FLJS_TRE)

Lahanna oy

Status: Completed

Conditions: Pocket Depth; Bleeding on Probing; Saliva Microbiome; Plaque Control

Treatments: Other: Fermented lingonberry juice sprey

Study type: Interventional

Funder types: Other

Identifiers

NCT07143344

TYH 2024332 (Other Grant/Funding Number)

Y2519SU010 (Other Grant/Funding Number)

LING_TRE

TYH2022225 (Other Grant/Funding Number)

TYH 2025382 (Other Grant/Funding Number)

Details and patient eligibility

About

A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.

Full description

Traditional clinical oral examinations, periodontal status and sample gatherings were performed at start point, two and four weeks. Bleeding on probing (BOP), visible plaque index (VPI), probing pocket depths (PPD) were examined and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml) were carried out. Additionally, stimulated and resting saliva, pH and buffering capacity were tested as saliva test. A questionnaire assessing dry mouth symptoms was also recorded from the patients.

Enrollment: 11 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy patients or patients with systemic diseases with good cognitive abilities
• with or without xerostomia.

Exclusion criteria

• use of other mouthwash products, including chlorhexidine
• current use of antibiotics.

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Adult patients were randomly selected from a private dental clinic in Tampere, Finland for the study

Experimental group

Description:

Participants used approximately ten sprays four times a day (approx. 5,5 ml/ day) of FLJ-spray (Lingora® Oral Spray, Berries United Ltd, Helsinki, Finland) for a month.

Treatment:

Other: Fermented lingonberry juice sprey