Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS)

Istanbul University

Status and phase: Completed; Phase 4

Conditions: Pain, Postoperative

Treatments: Drug: Thoracic paravertebral block (TPVB); Drug: Patient Controlled Analgesia (IV PCA)

Study type: Interventional

Funder types: Other

Identifiers

NCT02302586

46143867-1035

Details and patient eligibility

About

Video-assisted thoracoscopic surgeries (VATS) include severe postoperative acute pain which is also a predictor of chronic pain. In this study, the investigators aim to compare the postoperative effects of thoracic paravertebral block (TPVB) and intravenous patient controlled analgesia (PCA) on the prevention of chronic pain of patients undergoing VATS.

Full description

Video-assisted thoracoscopic surgeries (VATS) include significant postoperative acute and chronic pain because of trocar site tissue damages, intercostal nerve injuries and related inflammatory responses. Poorly controlled pain in the early postoperative period usually causes chronic pain, and also affects patients' physiotherapy, mobilization and daily function.

Our hypothesis in this study is 'thoracic paravertebral block (TPVB) is associated with an improvement in control of acute and chronic pain after VATS compared to systemic analgesia.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

ASA I-III Patients who undergo Video-assisted thoracoscopic surgery (VATS) under GA

Exclusion criteria

Patients with difficult understanding the instructions for using PCA and/or pain scales Patients with contraindication to regional anesthesia Patients with significant neurologic, psychiatric or cognitive disorders History of substance abuse or chronic opioid use

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Patient Controlled Analgesia (IV PCA)

Active Comparator group

Description:

Postoperative intravenous (IV) morphine PCA is being used for acute pain control: Basal infusion: 0.3 mg/kg/h Bolus: 1 mg, Lock-out time: 20 min, 4-h limit: 10-12,5 mg

Treatment:

Drug: Patient Controlled Analgesia (IV PCA)

Thoracic Paravertebral Block (TPVB)

Active Comparator group

Description:

Preoperative thoracic paravertebral block (TPVB) at 4 levels from T4 to T8 is being performed and total of 20 mL Bupivacaine 0.5% is deposited (5 mL per level by using landmark technique)

Treatment:

Drug: Thoracic paravertebral block (TPVB)