Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients

Nazmy Edward Seif

Status: Completed

Conditions: Lung Diseases; Nephrectomy; Anesthesia

Treatments: Procedure: Thoracic Epidural Anesthesia; Drug: Dexmedetomidine; Drug: Fentanyl; Drug: Bupivacaine 0.5% (isobaric); Procedure: Thoracic Spinal Anesthesia; Drug: Bupivacaine 0.5% (hyperbaric)

Study type: Interventional

Funder types: Other

Identifiers

NCT03324490

TSEANORLDP60

Details and patient eligibility

About

Patients with respiratory disease have an increased risk of developing complications perioperatively. The use of regional anesthesia decreases this risk with better postoperative outcome. The aim of this study is to compare the safety and efficacy of thoracic spinal versus thoracic epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease.

Enrollment: 60 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA class II or III
• Mild to moderate obstructive or restrictive lung disease
• Open nephrectomy candidate patients

Exclusion criteria

• Any condition contra-indicating regional anesthesia
• Allergic to any of the drugs used during the procedure

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 2 patient groups

TSA group

Active Comparator group

Description:

Thoracic Spinal Anesthesia; Bupivacaine 0.5% (hyperbaric) 7.5mg, Fentanyl 25 µg & Dexmedetomidine 5 µg by intrathecal injection

Treatment:

Drug: Bupivacaine 0.5% (hyperbaric)

Procedure: Thoracic Spinal Anesthesia

Drug: Fentanyl

Drug: Dexmedetomidine

TEA group

Active Comparator group

Description:

Thoracic Epidural Anesthesia; Bupivacaine 0.5% (isobaric) 25-50 mg & Fentanyl 10-20 µg by epidural injection

Treatment:

Drug: Bupivacaine 0.5% (isobaric)

Drug: Fentanyl

Procedure: Thoracic Epidural Anesthesia