Thoracoabdominal Arortic CTA Study

Duke University

Status and phase: Completed; Phase 4

Conditions: Thoracic Aortic Aneurysm

Treatments: Drug: Isovue

Study type: Interventional

Funder types: Other

Identifiers

NCT02291718

Pro00048275

Details and patient eligibility

About

The purpose of this study is to compare the contrast agents and imaging techniques used for thoracoabdominal aortic imaging in CT. Imaging parameters and contrast volume are changed and adjusted based on the contrast agent, since contrast agents have varying iodine concentrations. If the contrast iodine concentration is higher, it may be possible to adjust the imaging parameters and lower the overall radiation dose to the patient.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing thoracoabdominal aortic (TAA) CTA
• Able to provide informed consent
• Body Mass Index (BMI) equal to or less than 30

Exclusion criteria

• Creatinine greater than 2.0
• Allergy to contrast media
• Pregnant women

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 3 patient groups

Isovue 300 75mL

Active Comparator group

Description:

Isovue 300 75mL injected 120 kVp 250 mAs

Treatment:

Drug: Isovue

Isovue 370 75mL

Active Comparator group

Description:

Isovue 370 75mL injected 100 kVp 240 mAs

Treatment:

Drug: Isovue

Isovue 370 60mL

Active Comparator group

Description:

Isovue 370 60mL injected 100 kVp 240 mAs

Treatment:

Drug: Isovue