Threatened Preterm Birth and Time of Subsequent Delivery -a Prediction Model

Linköping University (LiU)

Status: Completed

Conditions: Immunologic Activity Alteration; Preterm Birth

Study type: Observational

Funder types: Other

Identifiers

NCT03796949

960624abc

Details and patient eligibility

About

This study investigates immunological and clinical markers in threatened preterm birth aiming to create a prediction model for preterm birth.

Full description

Preterm birth is the main cause of neonatal mortality and morbidity and despite a lot of effort the mechanisms leading to preterm birth are poorly understood. In threatened preterm birth it is difficult to identify the true high risk cases ultimately leading to preterm birth. These women are often overtreated.

In this study blood samples are taken from women with threatened preterm birth and from women with normal pregnancies before and during labor.

Differences in clinical characteristics and immunological markers between the groups are studied in order to design a prediction model for preterm birth.

Enrollment: 204 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Threatened preterm birth before 34 weeks of gestation; either threatened preterm labor and/or preterm prelabor rupture of the membranes
• Age > 18 years
• Swedish-speaking (understanding study information)

Exclusion criteria

• Multiple gestation
• Blood borne infections

Trial design

204 participants in 2 patient groups

threatened preterm birth

Description:

Women with either preterm labor or preterm prelabor rupture of the membranes. Blood samples taken at time of inclusion in the study.

Controls

Description:

Women with normal pregnancies. Blood samples taken at time of inclusion in the study, either prelabor (during pregnancy) or during active phase of labor.