Three Anaesthesic Method in Electroconvulsive Theraphy

Inonu University

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: Sevoflurane; Drug: Propofol; Drug: Remifentanil and propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT01759589

Inonu University

Inonu University Anesthesia

Details and patient eligibility

About

To compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane in ECT.

Full description

The purpose of this study is to compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane) with respect to seizure duration, postictal suppression index, early and midictal amplitude, hemodynamic variables and recovery profiles in ECT.

Enrollment: 39 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Upremedicated ASA I-II (American Society of Anesthesiologists's physical status) patients,
• Patients scheduled for six ECT sessions for a variety of psychiatric conditions (major depression, schizophrenia)

Exclusion criteria

• Involuntary patient status
• Patients with known or self-declared needle or mask phobia
• Pregnancy
• Asthma
• Cerebrovascular disease,
• History of myocardial infarction in the previous 6 months,
• Atrial fibrillation or flutter,heart block,
• A known or family history of reactions to the study drugs.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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39 participants in 3 patient groups, including a placebo group

propofol (Group P)

Placebo Comparator group

Description:

The patients in Group P received 1 mg/kg propofol IV (over 15 sec) during anesthesia induction

Treatment:

Drug: Propofol

remifentanil and propofol (Group R)

Active Comparator group

Description:

Patients in Group R received remifentanil 1 µg/kg IV (over 60 sec) and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction

Treatment:

Drug: Remifentanil and propofol

sevoflurane (Group S)

Active Comparator group

Description:

In Group S, sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered, at which time it was stopped.

Treatment:

Drug: Sevoflurane