Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus

Sohag University

Status: Completed

Conditions: Corneal Ectasia

Treatments: Procedure: Accelerated CXL; Procedure: Transepithelial CXL; Procedure: Standard CXL

Study type: Interventional

Funder types: Other

Identifiers

NCT05691335

10-4/2018

Details and patient eligibility

About

comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking

Full description

comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking for treatment of documented pediatric keratoconus progression. The study patients are divided into 3 groups. Group A patient treated with standard cross-linking. Group B patients treated with accelerated cross-linking. Group C patients treated with transepithelial cross-linking.

Enrollment: 97 patients

Sex: All

Ages: 12 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pediatric patient less than 18 years old
• keratoconus stage I-III ABCD keratoconus grading system

Exclusion criteria

• age more than 18 years
• previous eye surgery
• current eye infection or pathology

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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97 participants in 3 patient groups

Standard CXL

Other group

Description:

Patients treated according to Dresden Protocol with epithelium-off CXL.

Treatment:

Procedure: Standard CXL

Accelerated CXL

Experimental group

Description:

Patients treated according to accelerated Protocol with epithelium-off CXL.

Treatment:

Procedure: Accelerated CXL

Transepithelial CXL

Experimental group

Description:

Patients treated according to transepithelial Protocol with epithelium-on CXL.

Treatment:

Procedure: Transepithelial CXL