Three Different Therapy Regimens in Treating Patients With Previously Untreated Hodgkin Lymphoma

French Innovative Leukemia Organisation

Status and phase: Terminated; Phase 3

Conditions: Lymphoma

Treatments: Drug: cytarabine; Procedure: allogeneic hematopoietic stem cell transplantation; Drug: methylprednisolone; Biological: bleomycin sulfate; Drug: melphalan; Drug: cisplatin; Drug: vincristine sulfate; Drug: doxorubicin hydrochloride; Drug: vinorelbine tartrate; Drug: dexamethasone; Drug: carmustine; Drug: ABVD regimen; Procedure: autologous hematopoietic stem cell transplantation; Drug: mitoguazone; Drug: etoposide; Drug: ifosfamide; Drug: gemcitabine hydrochloride; Drug: dacarbazine; Drug: vindesine

Study type: Interventional

Funder types: Other

Identifiers

NCT00920153

LH 2007

Details and patient eligibility

About

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving drugs in different combinations may kill more cancer cells. It is not yet know which treatment regimen is more effective in treating Hodgkin lymphoma.

PURPOSE: This phase III trial is studying three different therapy regimens to compare how well they work in treating patients with previously untreated Hodgkin lymphoma.

Full description

OBJECTIVES:

Primary

• Evaluate event-free survival.

Secondary

• Evaluate overall survival.
• Evaluate the prognostic value of FDG-PET scanning.
• Evaluate progression-free survival.
• Evaluate tolerability.
• Evaluate rate of relapse.

OUTLINE: This is a multicenter study. Patients are assigned to 1 of 3 treatment groups according to prognosis.

• Group 1 (favorable prognosis): Patients receive ABVD chemotherapy comprising doxorubicin hydrochloride IV, bleomycin sulfate IV, vincristine sulfate IV, dacarbazine IV, and methylprednisolone IV on days 1 and 14. Treatment repeats every 28 days for 2 courses. Patients then undergo PET scan for evaluation of response. Patients receive additional treatment according to response.

  • Favorable response: Patients with favorable response receive 1 additional course of ABVD chemotherapy.
  • Unfavorable response: Patients with unfavorable response receive 1 course of VABEM chemotherapy comprising vindesine IV continuously on days 1-5, doxorubicin hydrochloride IV continuously on days 1-3, carmustine IV on day 3, etoposide IV on days 3-5, and methylprednisolone IV on days 1-5.

• Group 2 (intermediate prognosis): Patients receive 2 courses of ABVD chemotherapy. Patients then undergo PET scan for evaluation of response. Patients receive additional treatment according to response.

  • Favorable response: Patients with favorable response receive 4 additional courses of ABVD chemotherapy.
  • Unfavorable response: Patients with unfavorable response receive VABEM chemotherapy. Treatment with VABEM chemotherapy repeats every 28 days for 2 courses.

• Group 3 (poor prognosis): Patients receive 2 courses of VABEM chemotherapy. Patients then undergo PET scan for evaluation of response. Patients receive additional treatment according to response.

  • Favorable response: Patients with favorable response receive 1 additional course of VABEM chemotherapy.

  • Unfavorable response: Patients with unfavorable response receive CEO chemotherapy comprising cisplatin IV continuously on days 1-3, gemcitabine hydrochloride IV on days 1 and 8, and oral dexamethasone once daily on days 1-4. Treatment repeats every 21 days for 3 courses. Patients then undergo PET scan. Patients receive additional treatment according to response.

    • Favorable response: Patients with favorable response receive BEAM chemotherapy comprising carmustine IV on day -7, etoposide IV and cytarabine IV on days -6 to -3, and melphalan IV on day -2. Patients then undergo autologous stem cell transplantation on day 0.
    • Unfavorable response: Patients with unfavorable response receive MINE chemotherapy comprising mitoguazone IV, vinorelbine ditartrate IV, and ifosfamide IV on days 1-5 and etoposide IV on days 1-3. Treatment repeats every 28 days for 3 courses. Patients then undergo allogeneic or autologous stem cell transplantation.

Patients with favorable response or a "bulky" mass at diagnosis may also undergo radiotherapy.

After completion of study treatment, patients are followed periodically for 15 years.

Enrollment: 442 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

INCLUSION CRITERIA

• Life expectancy > 3 months
• LVEF normal
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Must be able to undergo follow-up for ≥ 15 years
• No impaired cardiac function that would preclude the administration of an anthracycline
• No other prior or concurrent malignancy, except for carcinoma in situ of the cervix or basal cell skin cancer
• No respiratory, kidney, or liver failure or other severe clinical insufficiency that would preclude study treatment
• No HIV or hepatitis B virus positivity
• No other disease that would preclude treatment with chemotherapy or radiotherapy

EXCLUSION CRITERIA:

• No concurrent participation in another experimental trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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442 participants in 3 patient groups

Group 1 (favorable prognosis)

Experimental group

Description:

Patients receive ABVD and VABEM chemotherapy.

Treatment:

Drug: etoposide

Drug: dacarbazine

Biological: bleomycin sulfate

Drug: methylprednisolone

Drug: carmustine

Drug: ABVD regimen

Drug: doxorubicin hydrochloride

Drug: vincristine sulfate

Drug: vindesine

Group 2 (intermediate prognosis)

Experimental group

Description:

Patients receive ABVD and VABEM chemotherapy.

Treatment:

Drug: etoposide

Drug: dacarbazine

Biological: bleomycin sulfate

Drug: methylprednisolone

Drug: carmustine

Drug: ABVD regimen

Drug: doxorubicin hydrochloride

Drug: vincristine sulfate

Drug: vindesine

Group 3 (poor prognosis)

Experimental group

Description:

Patients receive VABEM, CEO, BEAM, and MINE chemotherapy. Patients also undergo allogeneic or autologous stem cell transplantation.

Treatment:

Drug: ifosfamide

Drug: gemcitabine hydrochloride

Drug: mitoguazone

Drug: etoposide

Drug: dexamethasone

Drug: cytarabine

Drug: melphalan

Procedure: allogeneic hematopoietic stem cell transplantation

Drug: methylprednisolone

Drug: cisplatin

Drug: vinorelbine tartrate

Drug: carmustine

Drug: doxorubicin hydrochloride

Procedure: autologous hematopoietic stem cell transplantation

Drug: vindesine