Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Enrolling

Conditions: Conjunctival Diseases; Dry Eye Syndromes

Study type: Observational

Funder types: NETWORK

Identifiers

NCT03358979

EGN_2017_15

Details and patient eligibility

About

Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Patients:

Inclusion criteria

• 18 years and over
• Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
• Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced

Exclusion criteria - Known pregnancy or breastfeeding

Control subjects:

Inclusion criteria

- 18 years and over

Exclusion criteria

• Wearer of contact lenses
• Topical ocular treatment
• Known pregnancy or breastfeeding

Trial design

100 participants in 2 patient groups

Severe eye dryness

absence of eye dryness