Three-dimensional Assessment of Intraventricular Dyssynchrony Using Fast Dobutamine Gated SPECT (FAST DOGS)

Caen University Hospital

Status: Completed

Conditions: Heart Failure

Treatments: Other: myocardial perfusion scintigraphy

Study type: Interventional

Funder types: Other

Identifiers

NCT02510677

12-176

Details and patient eligibility

About

The prognosis of patients with heart failure has improved due to recent breakthrough in medical treatment and cardiac resynchronization devices. However, there is no paraclinical parameter to assess response to cardiac resynchronization therapy (CRT). This is a major issue since about a third of implanted patients will not be improved by CRT. CZT SPECT allows to perform myocardial perfusion imaging in less than 4 minutes and is able to study myocardial perfusion, viability, left ventricular function, but also ventricular asynchrony.

Using low-dose dobutamine gated SPECT and CZT camera, we aimed to assess left ventricular dyssynchrony in viable segments in patients with heart failure eligible for CRT.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with heart failure on optimal medical therapy and targeted for cardiac resynchronization therapy according to current recommendations;
• Age over 18 years
• Clinically stable (without hospitalization for heart failure in the last month)
• Sinus rhythm
• Social security insurance
• Signed consent form

Exclusion criteria

• Recent history (less than 21 days) of acute coronary syndrome or unstable angina;
• Recent history (less than 1 month) of acute heart failure;
• Right bundle branch block;
• Irregular heart rate;
• Double-chamber cardiac pacemaker
• Patients previously implanted with a single-chamber cardioverter-defibrillator must have at least 99 percent of unstimulated QRS.
• Countraindication to dobutamine therapy;
• Valvular heart disease, congenital heart disease, hypertrophic cardiomyopathy;
• Significant Ventricular arrhythmias;
• Hypertension (upper than 160/100 mmHg);
• Pregnant, breastfeeding or guardianship

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

myocardial perfusion scintigraphy

Other group

Description:

Low-dose dobutamine gated SPECT and CZT camera for the assessment of parameters of left ventricular dyssynchrony in heart failure patients eligible for the implantation of a cardiac resynchronization device.

Treatment:

Other: myocardial perfusion scintigraphy