Three Small Doses of HCG Versus Booster Dose of HCG on Ovum Pickup Day
Status and phase
Completed
Phase 4
Conditions
Infertility
Treatments
Procedure: IVF/ICSI
Drug: Human Chorionic Gonadotropin
Details and patient eligibility
About
To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared supplementing the luteal phase with three small doses (500 IU) of HCG and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.
Enrollment
200 patients
Sex
Female
Ages
20 to 37 years old
Volunteers
No Healthy Volunteers
Inclusion criteria
- High responder females undergoing antagonist protocol IVF/ICSI cycle
- More than 14 MII oocytes
- Estradiol more than 3500 pg/ml on day of trigger
Exclusion criteria
- Any other protocol
- Normal or poor responders
Trial design
Primary purpose
Treatment
Allocation
Randomized
Interventional model
Parallel Assignment
Masking
None (Open label)
200 participants in 2 patient groups
Small doses of HCG
Active Comparator group
Description:
Supplementing the luteal phase with three small doses (500 IU) of HCG after trigger with GnRH agonist in antagonist IVF/ICSI cycles in high responders
Treatment:
Drug: Human Chorionic Gonadotropin
Procedure: IVF/ICSI
Booster HCG dose
Active Comparator group
Description:
Booster HCG dose GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup
Treatment:
Drug: Human Chorionic Gonadotropin
Procedure: IVF/ICSI
Trial contacts and locations
3
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Data sourced from clinicaltrials.gov
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