Thresholds In Food Allergy evaluaTion And predictioN (TITAN)

Hamilton Health Sciences (HHS)

Status: Enrolling

Conditions: Food Allergy; Tree Nut Allergy

Treatments: Diagnostic Test: Oral food challenge

Study type: Observational

Funder types: Other

Identifiers

NCT06038019

NIF-20500

Details and patient eligibility

About

Thresholds In food allergy evaluaTion And predictioN, a prospective, observational registry. The aim is to quantify food allergy thresholds in Canada and their clinical predictors.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 3 months to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Suspicion or history of food allergy based on medical history, positive skin prick test, and/or serum food-specific IgE. A suggestive history is defined as typical clinical signs and/or symptoms (urticaria, angioedema, abdominal pain, vomiting, dyspnea, wheeze) within 60 minutes of the ingestion of a food.
2. Ability to discontinue all antihistamines for 1 week before oral food challenge.

Exclusion criteria

1. Previous desensitization treatment to a food allergen
2. Allergies to any component of the oral challenge vehicle
3. Unstable conditions including uncontrolled asthma or chronic urticaria
4. Any clinically significant disease/chronic medical condition which may interfere with study evaluations.

Trial design

2,000 participants in 1 patient group

Group 1

Description:

Patients with suspected or confirmed food allergy

Treatment:

Diagnostic Test: Oral food challenge