Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome

Assiut University

Status: Enrolling

Conditions: Hepatic Impairment; Hepatic Encephalopathy; Hepatic Failure; Hypothyroidism

Treatments: Diagnostic Test: hypothroidism; Diagnostic Test: euothyroid

Study type: Observational

Funder types: Other

Identifiers

NCT06179368

IRB121223

Details and patient eligibility

About

Liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to triiodothyronine (T3) by Type 1 deiodinase.

Full description

In clinical terms, cirrhosis is described as are either "compensated" or "decompensated." Decompensation means cirrhosis complicated by one or more of the following features: jaundice, ascites, hepatic encephalopathy (HE), or bleeding varices. Ascites is the usual first sign. Hepatorenal syndrome, hyponatremia, and spontaneous bacterial peritonitis are also features of decompensation, but in these patients, ascites invariably occurs first. Compensated cirrhotic patients have none of these features.

The liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to T3 by Type 1 deiodinase.

T4 and T3 regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic function. The liver metabolizes the THS and regulates their systemic endocrine effects. Thyroid diseases may perturb liver function; liver disease modulates thyroid hormone metabolism; and a variety of systemic diseases affect both the organs.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hepatic fauiure patients

Exclusion criteria

• hypethyroid patients

Trial design

100 participants in 2 patient groups

Hypothroid group

Description:

throid fuction will be evaluated on admission of hepatic failure patients, and the hypothroid patients will be enroled in this group.

Treatment:

Diagnostic Test: hypothroidism

Euthroid group

Description:

throid fuction will be evaluated on admission of hepatic failure patients, and the euothroid patients will be enroled in this group.

Treatment:

Diagnostic Test: euothyroid