Thrombectomy in ST Elevation Myocardial Infarction, an Individual Patient Meta-analysis

Population Health Research Institute (PHRI)

Status: Completed

Conditions: Acute Coronary Syndromes; Myocardial Infarction

Treatments: Device: Manual Aspiration Thrombectomy

Study type: Observational

Funder types: Other

Identifiers

NCT02552407

ThrombectomyMetaAnalysis

Details and patient eligibility

About

During primary percutaneous coronary intervention, distal embolization of thrombus and impaired microvascular perfusion has been associated with an increased mortality. Thrombectomy devices during primary percutaneous coronary intervention may prevent distal embolization by reducing thrombus burden and thus improve microvascular perfusion and reduce mortality.

Full description

An individual patient meta-analysis of large randomized controlled trials comparing manual thrombectomy versus percutaneous coronary intervention alone in patients with ST elevation myocardial infarction will provide significantly more power to detect differences in mortality as well as important but rare events such as stroke and to assess benefits in pre-defined subgroups.

Enrollment: 18,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Randomized controlled trials comparing manual thrombectomy vs. percutaneous coronary intervention alone in patients with ST elevation myocardial infarction published between January 1980 and April 2015.
• Large trials randomizing more than 1000 patients.
• Trials must have had at least 30 day follow up.

Exclusion criteria

Trial design

18,000 participants in 2 patient groups

Manual Aspiration Thrombectomy with PCI

Description:

Subjects from the randomized controlled trials to be included in this meta-analysis will have been randomly allocated to Manual Aspiration Thrombectomy followed by percutaneous coronary intervention (PCI).

Treatment:

Device: Manual Aspiration Thrombectomy

PCI Alone

Description:

Subjects from the randomized controlled trials to be included in this meta-analysis will have been randomly allocated to percutaneous coronary intervention (PCI) alone without manual aspiration thrombectomy.