Thrombo Embolic Events in Critical Care Patients With Covid-19 Serious Acute Pneumopathy (THROMBOCOVID)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: COVID-19; Hemostasis; Coagulation; Pneumonia; ARDS

Treatments: Other: venous ultrasound; Other: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT04366752

PI2020_843_0036

Details and patient eligibility

About

The understanding of haemostasis and inflammation cross-talk has gained considerable knowledge during the past decade in the field of arterial and venous thrombosis. Complex and delicately balanced interaction between coagulation and inflammation involve all cellular and humoral components. Elements of the coagulation system such as activated thrombin, fibrinogen or factor Xa may increase inflammation by promoting the production of pro-inflammatory cytokines, chemokines, growth factors and adhesion molecules that lead to a procoagulant state amplifying the pathological process. Recent evidence supports inflammation as a common pathogenic contributor to both arterial and venous thrombosis, giving rise to the concept of inflammation-induced thrombosis.

Patients with infection of COVID-19 and severe pneumoniae seem to have higher risk of thromboembolism. Very few data are available regarding the biological disorders of coagulation in these patients. Th purpose of this project is to analyze hemostasis and coagulation of patients with infection of COVID-19 and severe pneumonia.

Enrollment: 130 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients hospitalized in medical ICU with pneumonia due to COVID-19 infection

Exclusion criteria

• patients< 18 years