Thromboelastogram During Total Knee Replacement

Rambam Health Care Campus

Status: Completed

Conditions: Orthopedic Procedures, Tranexamic Acid

Study type: Observational

Funder types: Other

Identifiers

NCT02373969

TEG-099-11

Details and patient eligibility

About

Verify the changes in coagulation system during total knee replacement surgery with tranexamic acid single bolus infusion.

Full description

The study was set to reveal changes in the coagulation and fibrinolytic systems during total knee surgery and especially during tourniquet placement, tourniquet removal and revascularization of ischemic limb, after tranexamic acid single bolus infusion, and at post operative day 1.

Enrollment: 30 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Osteoarthrosis
• TKR operation elective
• ASA I-III

Exclusion criteria

• TKR due to any reason but osteoarthrosis
• known coagulation problems
• platelets < 100,000/DcL
• Hb < 12 g%
• past thrombo-embolic event
• treatment with aspiring during last week
• treatment with NSAID's during last 48 hours
• malignancy
• known allergy to tranexamic acid
• general anesthesia