Thromboelastometry in Liver Transplantation

Hospital Clinic of Barcelona

Status: Unknown

Conditions: Coagulopathy; Liver Transplant Disorder

Treatments: Other: Fibrinogen and/or platelets administration

Study type: Interventional

Funder types: Other

Identifiers

NCT03011827

ATR100F

Details and patient eligibility

About

Thromboelastometry better assess coagulation than standard coagulation test in patients undergoing ortothopic liver transplantation. In a post-hoc analysis from a randomized study recently conducted by our group, presurgical values of MA10 Extem < 35 mm are highly predictive of RBC administration , with no further improvement over MA10 Extem >40 mm ; suggesting that MA10 Extem between 35-40 would be the optimal range to manage blood product administration. The aim of the study is to validate this result in a prospective cohort of patients submitted to ortothopic liver transplantation.

Enrollment: 65 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presurgical hemoglobin < 13 d/L and clot firmness at 10 minutes Extem < 35 mm

Exclusion criteria

• Previous thrombosis
• Antithrombotic treatment
• No consent

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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65 participants in 1 patient group

Prospective cohort

Experimental group

Description:

Fibrinogen and/or platelet administration

Treatment:

Other: Fibrinogen and/or platelets administration