Thrombophilia Assessment Under DOAC: Effectiveness of Activated Charcoal (DOAC-Stop)

University Hospital, Strasbourg, France

Status: Enrolling

Conditions: Thrombophilia

Study type: Observational

Funder types: Other

Identifiers

NCT06171984

8673

Details and patient eligibility

About

Direct oral anticoagulants (DOAC) are anticoagulant molecules that act either directly on factor Xa (Apixaban, Rivaroxaban) or on factor IIa (Dabigatran).

AODs interfere with most coagulation tests, especially those performed by chronometric technique.

For this reason, part of the thrombophilia workup (protein S, search for lupus anticoagulants, antithrombin for patients on dabigatran) cannot be performed on DOACs at the HUS.

Recent studies have highlighted the effectiveness of activated charcoal to adsorb DOACs in order to perform certain hemostasis tests.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult subject (≥ 18 years of age)
• Blood sample already analyzed in a usual way in the laboratory as part of the care
• Subject not objecting to the reuse of his or her medical data for scientific research purposes.

Exclusion criteria

• Insufficient sample