Thrombospondin-1 and Pigmented Epithelium Derived Factor Levels in Patients With Diabetes Mellitus. (PEDF)

MidAtlantic Retina

Status: Completed

Conditions: Diabetes; Diabetes Mellitus

Treatments: Biological: Blood draw

Study type: Observational

Funder types: Other

Identifiers

NCT01809093

IRB# 09-954 (Other Identifier)

09-954

Details and patient eligibility

About

You are being asked to be in a research study to determine blood levels and vitreous levels of compounds called thrombospondin 1 (TSP1) and pigment epithelium derived factor (PEDF). These compounds exists naturally in your body.

Full description

The hypothesis tested here is that diabetic patients that express the higher molecular weight pigment epithelium-derived factor (PEDF) isoform have lower thrombospondin-1 (TSP1) level and, as a result, are at a greater risk for the development of more severe diabetic retinopathy.

Enrollment: 90 patients

Sex: All

Ages: 18+ minutes old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ability to provide written informed consent and comply with study assessments for the full duration of the study
• Diabetes Mellitus
• Undergoing pars plana vitrectomy for any reason

Exclusion criteria

• Use of any anti-VEGF (vascular endothelial growth factor ) medications

Trial design

90 participants in 1 patient group

Blood draw

Description:

Blood (approximately equal to 3 to 4 tablespoons) will be drawn at the Wills Eye Institute, 1 time.

Treatment:

Biological: Blood draw