Thrombus Aspiration in Myocardial Infarction (TASTE)

Region Örebro County

Status: Completed

Conditions: Acute Myocardial Infarction

Treatments: Procedure: Thrombus aspiration

Study type: Interventional

Funder types: Other

Identifiers

NCT01093404

SCAAR-001

Details and patient eligibility

About

Treatment of myocardial infarction (blood clot in the arteries of the heart) has improved after introduction of 24/7 balloon angioplasty to open the blocked artery. However, the clot itself is not routinely removed but recent data in smaller trials indicate that this might improve recovery and prognosis. In this multicenter study of 5000 patients referred to Scandinavian hospitals for myocardial infarction the investigators test the hypothesis that patients randomized to treatment with thrombus aspiration (removing the blood clot by manual suction) before conventional angioplasty will have a reduced risk of death, fewer rehospitalisations, fewer new myocardial infarctions, reduced risk of heart failure, better coronary artery flow after angioplasty and greater reduction of infarct size compared to patients randomized to conventional angioplasty alone.

Enrollment: 7,243 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a diagnosis of ST-segment elevation myocardial infarction
• Correspondence between ECG findings and culprit artery pathoanatomy
• A minimum of 50% stenosis in culprit artery by visual estimate
• Possibility to perform thrombus aspiration

Exclusion criteria

• Need for emergency coronary artery bypass grafting
• Inability to provide informed consent
• Age below 18 years
• Previous randomization in the TASTE trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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7,243 participants in 2 patient groups

Thrombus aspiration

Experimental group

Description:

Thrombus aspiration is then followed by standard balloon angioplasty (PCI).

Treatment:

Procedure: Thrombus aspiration

Standard balloon angioplasty (PCI)

Active Comparator group

Treatment:

Procedure: Thrombus aspiration