Thrombus Imaging and Treatment Analytics in Neurology (Titan)

Chinese PLA General Hospital (301 Hospital)

Status: Enrolling

Conditions: Thrombosis; Thrombus, Brain

Treatments: Diagnostic Test: thrombus imaging appearance

Study type: Observational

Funder types: Other

Identifiers

NCT05663281

301Titan

Details and patient eligibility

About

In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.

Full description

Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Extracranial and/or intracranial artery occlusion confirmed by angiography
• Available for magnetic resonance high-resolution vessel wall imaging
• Written informed consent obtained

Exclusion criteria

• Extracranial and/or intracranial artery mild to moderate stenosis
• Pregnant women
• Restenosis or occlusion after artery stenting placement