Thyme Honey for Management of Oral Lichen Planus

British University In Egypt

Status and phase: Invitation-only; Phase 2; Phase 1

Conditions: Oral Lichen Planus

Treatments: Dietary Supplement: thyme honey; Drug: Triamcinolone Acetonide

Study type: Interventional

Funder types: Other

Identifiers

NCT06810752

24-092

Details and patient eligibility

About

the study aimed to assess the effect of topical application of thyme honey in comparison to 0.1% triamcinolone acetonide oral paste on the relief of pain and clinical improvement in patients with OLP

Enrollment: 30 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:• Patients clinically and histopathologically (if required) diagnosed as suffering from OLP.

• Patients free from any visible oral lesions other than OLP.
• Patients who agreed to take supplied medications.
• Patients who agreed for the biopsy (when required).

Exclusion Criteria:• •Patients suffering from any systemic disease.

• Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
• Treatment with any oral topical medications for at least four weeks prior to the study.
• Pregnant and lactating women.
• In addition, no consideration was given to patients with a history of hypersensitivity to honey.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups, including a placebo group

Thyme Honey group

Active Comparator group

Description:

Topical application of Thyme Honey

Treatment:

Dietary Supplement: thyme honey

Control group

Placebo Comparator group

Description:

Topical application of Triamcinolone acetonide

Treatment:

Drug: Triamcinolone Acetonide