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Thyroid and Cortisol Hormone Response to Sepsis

A

Assiut University

Status

Not yet enrolling

Conditions

Sepsis

Study type

Observational

Funder types

Other

Identifiers

NCT06289179
Thyroid and cortisol in sepsis

Details and patient eligibility

About

Thyroid and cortisol hormone response to sepsis

Full description

Sepsis is dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents.

Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance.

In response to any psychological or physical stressor, there is widespread neurohormonal activation to adapt body with the stressor. Production and secretion of stress hormones increase to modulate behaviour Many studies have been performed investigating specific hormonal perturbations such as critical illness-induced corticosteroid insufficiency ,all of which are associated with worse outcomes and poor of body inflammation. However, the endocrine system as a whole has been largely overlooked as a fundamental contributor to the integrated host response to sepsis thyroid axis is affected during sepsis with decreased pituitary release of thyroid stimulating hormone (TSH) and inhibition of the peripheral conversion of thyroxine (T4) by 5-deiodinase to the much more metabolically active triiodothyronine (T3). High cortisol levels also inhibit this enzymatic conversion.

Enrollment

114 estimated patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • The study will include Adults (≥18 years), both genders
  • septic patients admitted to critical care unit

Exclusion criteria

  • thyroid disease
  • hypopituitarism
  • Addison disease
  • Cushing syndrome)

Trial contacts and locations

0

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Central trial contact

Mohamed Hossam Aldin Hassan, Professor; Sara Mahmoud khalf allah Mohamed

Data sourced from clinicaltrials.gov

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