Thyroid Artery Embolization for the Treatment of Compressive Goiters. (TAE)

Université de Sherbrooke

Status: Enrolling

Conditions: Thyroid Nodules

Treatments: Procedure: Thyroid Artery Embolization

Study type: Interventional

Funder types: Other

Identifiers

NCT07360587

2025-5830

Details and patient eligibility

About

Very few studies have investigated TAE as a treatment for goiter with compressive symptoms. What is the efficacy and safety of TAE for the treatment of compressive goiters in a population ineligible for or refusing standard therapy? This is a prospective interventional cohort study that will allow us to standardize imaging by improving quality data collection and fellow-up to assess the efficacy of TAE for compressive symptoms of nodular goiters. Not only to corroborate current emerging results but clearly define the expected results for this technique.

Full description

This study is a prospective interventional cohort study.

The prospective cohort setting allows us to evaluate the direct effect of TAE on a series of patients on a longer period and to strengthen the retrospective data previously documented in other studies.

Included patients will have compressive symptoms or significant tracheal or oesophageal compression at risk of causing symptoms attributed to a goiter.

They have to be Ineligible for surgery/ablative treatments or preference for TAE over other treatments.

There is no comparative group in our study as it aims to prove that TAE is effective and safe in a "nonsurgical" population, a population in which other alternatives lack or are refused by the patient.

Our sampling method will be a non-probabilistic convenience sampling. Patients will be recruited in an outpatient setting by the patient's treating endocrinologist or otolaryngologist.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with compressive symptoms or significant tracheal or oesophageal compression at risk of causing symptoms attributed to a goiter AND
• Ineligible for surgery/ablative treatments or preference for TAE over other treatments AND
• TiRADS category 1, 2, 3 or 4 AND
• Bethesda categories I or III on 2 different biopsies OR Bethesda II on one biopsy AND
• Patient at least 18 years old.

Exclusion criteria

• Comorbidities precluding endovascular procedure OR
• TiRADS category 5 OR
• Bethesda categories IV, V, VI on biopsy OR
• Refusal of the patient to participate OR
• Uncontrolled severe hyperthyroidism OR
• Minor patient.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Thyroid Artery Embolization

Experimental group

Description:

Patients with diagnosis of Goiter with compressive symptoms in which other alternatives lack or are refused by the patient himself.

Treatment:

Procedure: Thyroid Artery Embolization