Thyroid-Associated Ophthalmopathy Subtypes and Orbital Antibodies

Barwon Health

Status: Completed

Conditions: Graves' Ophthalmopathy

Treatments: Drug: Carbimazole, radio-active iodine (I131)

Study type: Interventional

Funder types: Other

Identifiers

NCT00430547

03/53

Details and patient eligibility

About

The purpose of this study is to determine whether radioactive iodine, as compared to anti-thyroid medications, is a risk factor for the development or progression of thyroid-associated ophthalmopathy in patients with hyperthyroidism due to Graves' disease. The other aim of this study is to determine the incidence of the various ophthalmopathy subtypes and the utility of orbital antibodies in the diagnosis, classification and monitoring of patients with thyroid-associated ophthalmopathy.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Graves' disease diagnosed in the last 3 months, regardless of the presence of ophthalmopathy

Exclusion criteria

• Pre-existing eye disease: e.g. orbital surgery, orbital irradiation or significant loss of vision
• Age < 18 years
• Inability to consent to participation in the study
• Pregnancy
• History of radio-active iodine therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)