Thyroid Dysfunction Induced by Anti-PD-1 Therapy in Patients With Advanced Carcinoma

Shandong University

Status: Completed

Conditions: Carcinoma

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05593744

SDU-KYLL-202208-042

Details and patient eligibility

About

In this study, we monitored patients with advanced malignant tumors who received anti-PD-1 therapy to observe the characteristic of anti-PD-1 therapy-induced thyroid dysfunction and its correlation with prognosis.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Eighteen years or older
• Confirmed diagnosis of malignancy
• Received anti-PD-1 therapy

Exclusion criteria

• Thyroid malignancy or history of thyroid malignancy
• Thyroid dysfunction before anti-PD-1 therapies
• Previous ICIs treatment
• Less than 2 cycles of anti-PD-1 treatment
• No thyroid function monitoring during treatment
• Known pituitary disease
• Pregnancy.

Trial design

100 participants in 2 patient groups

Thyroid dysfunction

Description:

Patients had thyroid dysfunction during anti-PD-1 therapy.

Treatment:

Other: no intervention

No thyroid dysfunction

Description:

Patients didn't have thyroid dysfunction during anti-PD-1 therapy.

Treatment:

Other: no intervention